fotonolNol Brouwers, an experienced engineer and entrepreneur, is the director and founder of DermalDose. He studied mechanical engineering at the Technical University Twente. After his graduation in production engineering and factory automation, he started his industrial career at Texas Instruments Holland (TIH), and became the mechanization manager, a department of 80 people that was responsible for factory automation at TIH.

After a few years he founded a new engineering company in Almelo, Technécon Twente, which served major Dutch industries, like the several Philips factories, DICO, DSM, DE, Unilever, AKZO, etc.

He returned to Texas Instruments to become the European Engineering manager, with engineering and automation responsibilities for the appliance, automotive and RFID business units. He was member of the European and the Global Engineering Councils of TI. In this period he was trained in topics like Strategic Leadership, Quality Management, High Tech Marketing and Strategic Market Assessment.

In 1997 Texas Instruments decided to relocate all components production activities to other areas. Upon this decision he decided to leave Texas Instruments to found, together with Gerard Huiberts, Integrated Mechanization Solutions (IMS), based on the mechanization department of TIH. IMS today is part of the WWINN-group, a worldwide player for factory automation projects for high volume precision parts.

After 15 years of leading his company, Nol Brouwers decided to pass on his responsibilities within WWINN-group and focus on the development of the DermalDose system.

Our mission is to deliver a method for intradermal drug delivery, which is user-friendly, precise, and reliable.

In the time that Nol Brouwers, founder and director of DermalDose, was director of Integrated Mechanization Solutions (IMS), he got involved in microneedle development. IMS was asked to do design and prototyping work on the ViaDerm microneedle arrays by TransPharma Medical, an Israelian start-up company with close contacts with TEVA. Eventually a production line for the ViaDerm Arrays was build. On this ISO 13485, GMP and clean room production line several 100 ku samples of the ViaDerm arrays were manufactured for clinical trials by TransPharma Medical and Eli Lilly, the huge US based pharmaceutical company.

Also IMS participated in a STW scientific research program on microneedle developments, headed by Professor Dr. Joke Bouwstra of the University of Leiden. She received a Simon Stevin Award for her work in the field of transdermal drug delivery. In the STW project Nol Brouwers learned about microneedles, the skin and the potential benefits of these needle if used as an alternative for injection needles.

However, the microneedles of TransPharma Medical and in the STW program were solid. After puncturing the skin, the medicine needed to be delivered by an adhesive plaster with dried medicine dots that was stuck on the perforated skin. Unfortunately, only small amounts of drug can be delivered by this method.

Together with his son Bouke, Nol Brouwers felt that hollow micro needles would allow higher doses to be delivered directly in the dermis. Together they started a development for hollow needles that would enable a reliable delivery of drugs directly in the dermis. This development resulted in several patents for an intradermal drug delivery system, which is now known as the DermalDose system.

The DermalDose team exists out of highly experienced professionals working together with young professionals and students of the University of Twente, ensuring a broad variety of expertise.

Nol Brouwers, Founder and Director

Former European Engineering Manager Texas Instruments
Founder of IMS and the WWINN-group

Luuk Jansen, Marketing & Business Development

Master Management of Product Development – University of Twente

Robert Spel Engineer

Bachelor Mechanical Engineering

Hanneke Pouw,  Medical Research 

Master Technical Medicine - University of Twente

Thomas Verloop, Engineer

Msc Emerging Technology Design for Biomedical Devices

Kicky van Leeuwen, Research

Master Technical Medicine – University of Twente

Dr. Andrew Kirby, Consultant

Pharmacology, Cardiff UK

Ton Denissen, Consultant

Quality audit, CE Marking

Rikus Eising, Consultant

Business Development